Endocrine Abstracts

Visfatin is a newly discovered protein secreted by adipose tissue, which is suggested to play a role in pathogenesis of insulin resistance. Polycystic ovary syndrome (PCOS) is heterogeneous disorder, where insulin resistance might be involved in the development of endocrine and metabolic abnormalities. The aim of the present study was to asses the relation between serum visfatin and insulin sensitivity and markers of hyperandrogenism in a lean and obese PCOS patients. The stud...

The pathogenesis of insulin resistance is not completely understood, however, there are data that it might be associated with altered tissue carbohydrate and lipid oxidation. Adiponectin may be a key regulator of insulin sensitivity and energy metabolism. The aim of the present study was to determine the association of adiponectin, glucose metabolism (oxidation and storage) and lipid oxidation by applying the euglycemic clamp technique and indirect calorimetry.<p class="ab...

Adropin, hormone playing an important role in carbohydrates and lipids metabolism, improves mainly the glucose homeostasis. It could also play a protective role in pathogenesis and development of cardiovascular diseases. The purpose of the study was to assess the adropin concentration and some parameters of nutritional status (BMI, WHtR, BAI, VAI) as well as biochemical parameters (fasting glucose and insulin, and lipid profile). 25 patients (84% of group was women, n...

Visfatin (pre-B cell colonyenhancing factor) is a adipocytokine playing an important role in glucose homeostasis. High concentrations of visfatin are observed in obese people. Previous studies suggest that estimation of visfatin concentration could be a promising tool for predicting obesity or its metabolic consequences. The aim of the study was to evaluate the correlation between visfatin concentration, selected anthropometric parameters (BMI, WHR, BAI, VAI index) and biochem...

Introduction: 18F- Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (18F-PSMA PET/CT) is currently used in the evaluation of prostate cancer. Due to increased expression of PSMA in the neovascular endothelial cells of malignant lesions other than prostate cancer, PSMA PET/CT has become of interest to researchers in the management of thyroid cancer. The goal of this study was to evaluate the incidence and clinical signifi...

Introduction: Paragangliomas are rare neuroendocrine neoplasms arising from chromaffin cells in the sympathetic or parasympathetic neural paraganglia that may appear in many places throughout the body. These might be benign or malignant tumors. We report an interesting case of disseminated paraganglioma, the diagnosis of which began with the metastasis to the thyroid gland.Case presentation: A 69-year-old patient with a history of toxic multinodular goit...

Introduction: In recent years the growing rate of newly diagnosed papillary tyroid cancers (PTC) has been observed. Nowadays most of PTC are small (mostly <2cm in diameter) with no unfavourable patomorphological features, although the cases of incompletely resected PTC can still be encountered. Incomplete tumour resection, regardless of the presence of microscopic (R1) or macroscopic (R2) disease, after operation, is considered as a high-risk factor for PTC recurrence/pers...

Introduction: Several investigations proved the presence of receptors for androgens, estrogens and progesterone in vocal folds. The most common endocrine disorder causing alterations in the aforementioned hormones concentrations is polycystic ovary syndrome (PCOS), which, according to several studies, can cause voice changes, especially deepening of its timbre. Over last few years, vocal changes accompanying many different disorders have been a subject of research with the use...

Introduction: Selenium (Se) deficiency is a known risk factor for autoimmune thyroid diseases including Graves’ orbitopathy (GO).Objective: To determine the concentration of Se in serum and to determine the dependency of Se concentration on known markers of disease severity: the TRAB levels and the CAS (clinical activity score) in patients with GO.Material: 64 patients (50 women, 14 men; average age- 54.5 years) with active, m...

Background: Irisin is an adipokine/myokine which could be connected with insulin sensitivity. Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovary, hyperandrogenism and insulin resistance.Objective: The aim of the present study was to determine the relationship between serum irisin concentration and insulin sensitivity (Mffm) as well as the effect of insulin infusion on circulating irisin levels in PCOS ...